Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.
نویسندگان
چکیده
New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 52 12 شماره
صفحات -
تاریخ انتشار 2008